Endotoxins o ni molela'au lipopolysaccharides hydrophobic (LPS) e maua mai i siama o lo'o maua i totonu ole sela pito i fafo ole siama kalama leaga.Endotoxins e aofia ai se filifili polysaccharide autu, O-specific polysaccharide itu filifili (O-antigen) ma se lipid compenent, Lipid A, lea e nafa ma aafiaga oona.O siama e fa'amaligiina le endotoxin i se aofaiga tele pe a oti sela ma pe a olaola ma vaeluaina.E tasi le Escherichia coli o lo'o iai pe tusa ma le 2 miliona mole mole LPS ile sela.
E mafai e le Endotoxin ona faigofie ona fa'aleagaina labwares, ma o lona i ai e mafai ona matua fa'asoaina uma i vitro ma in vivo fa'ata'ita'iga.Ma mo oloa faamatua, o oloa faamatua ua afaina i endotoxins e aofia ai le LPS e mafai ona oo atu ai ile fiva, fa'aosoina ole tali inflammatory, te'i, faaletonu okeni ma le oti ile tagata.Mo oloa fa'amama toto, e mafai ona fa'afeiloa'i le LPS e ala i le membrane ma le pore lapo'a e ala i tua-filtration mai le vai fa'amama toto i le toto, e ono mafua ai fa'afitauli inflammatory.
Ole Endotoxin e maua ile Lyophilized Amebocyte Lysate (TAL).Bioendo ua faʻamaoni i suʻesuʻega, atinaʻe ma gaosia TAL reagent mo le silia ma le fasefulu tausaga.O a matou oloa e aofia uma auala e faʻaaogaina e suʻe ai le endotoxin, o le gel-clot technique, turbidimetric technique, ma le chromogenic technique.
Taimi meli: Ian-29-2019
